Sioux Falls (Mitchell), SD

Sioux Falls is the state’s largest city and most important commercial and cultural center. This Midwestern city has a strong and diverse economy based not only on local activities like agriculture but also a significant presence in the service economy, especially banking and credit processing. Because of low taxes, a good labor force, and business-friendly state laws, Wells Fargo, Citibank, HSBC, and others have large processing operations here. Sioux Falls is also a healthcare hub for a large region of South Dakota, Iowa and Minnesota. The unemployment rate in Sioux Falls is 3.40 percent which is almost half the US average. The top employers are Sanford Health, Avera Health, Smithfield Foods, and Wells Fargo.